Figure 3.

Effects of dimeric HHP-RNase on murine fibroblasts. Malignant SVT2 fibroblasts (closed symbols) or normal 3T3 fibroblasts (open symbols) were grown in the absence or in the presence of HHP-RNase (squares), BS-RNase (circles), monomeric LCCK-HP-RNase (triangles), or wild-type HP-RNase (rhombs). Cell survival values (means of triplicates) are expressed as percent of the corresponding values obtained in control cultures grown in the absence of protein. (A) Cell survival in the presence or in the absence of 50 μg/ml RNase. (B) Dose–response curves after 48 h of incubation.