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Tumor cells sensitized to apoptosis by HHP-RNase. HDFs and human thyroid tumor (NPA) cells were grown, were exposed for 72 h to HHP-RNase (25 μg/ml), and were fixed and stained with Hoechst immunofluorescent reagent. (A) Untreated HDF cells. (B) HDF cells exposed to HHP-RNase. (C) Untreated NPA cells. (D) NPA cells exposed to HHP-RNase. The inset shows a fragmented and condensed apoptotic nucleus from an NPA treated cell. (A–D, ×360; D Inset, ×2,400.)
