Table 1.
Cytotoxic effect of dimeric HHP-RNase on human tumor cells
| Tumor | Cell line | IC50, μg/ml
|
|
|---|---|---|---|
| HHP-RNase | BS-RNase | ||
| Rhabdomyosarcoma | SJRH 30 | 2.0 | 2.3 |
| Neuroblastoma | UFK-NB-3 | 2.6 | 0.4 |
| Medulloblastoma | D-283 | 17.9 | 14.3 |
| Glioblastoma | U 373 | 33.6 | 7.1 |
| Melanoblastoma | PBF-M-1 | 38.9 | 54.8 |
| Laryngeal carcinoma | Hep2 | 85.7 | 35.7 |
The IC50 values represent the protein concentrations that produce 50% of the total cytotoxic effect, measured for each cell line in a dose–response curve with a range of protein concentration of 0.4–200 μg/ml.