Figure 1.

Structures of ZL₃B (A) and bortezomib (B). Inhibition of 3D7 (closed squares), HB3 (open squares), W2 (open circles), and Dd2 (open triangles) parasite clones as a function of ZL₃B (C), bortezomib (D), pyrimethamine (E) and chloroquine (F) concentrations. The clones of P. falciparum used in this study were obtained from the Malaria Research and Reference Reagent Resource Center (MR4). IC₅₀'s are represented in nM. Values are means ± standard deviation of three independent experiments each performed in triplicate.