Table 2.
List of 15 genes significantly differentially expressed at the P < 0.001 level between BTB-infected cattle (n = 6) and control cattle (n = 6) from the BOTL-5 microarray data
| Array feature/Clone ID | Gene symbol | Gene name | Gene ontology (GO) function/s | Infected vs control animal relative expression |
| NBFGC_AW656075 | NCOR1 | Nuclear receptor co-repressor 1 | DNA binding, protein binding, transcription corepressor activity | -2.12 |
| NBFGC_BF604459 | PPP2R5B | PP2A protein phosphatase 2A B56-beta | Protein phosphatase type 2A regulator activity | 1.43 |
| BOTL0100001XG10R | UCP2 | Uncoupling protein 2 (UCP2) (mitochondrial, proton carrier) | Binding, transporter activity | -1.80 |
| BOTL0100002XD04R | UNC84B | Unc-84 homolog B | Microtubule binding | -1.58 |
| BOTL0100003XB12R | ZDHHC19 | Zinc finger, DHHC-type containing 19 | Acyltransferase activity, metal ion binding, transferase activity, zinc ion binding | 1.94 |
| BOTL0100003XF01R | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Protein binding, transcription factor activity | -2.28 |
| BOTL0100004XD01R | GAN | Giant axonal neuropathy (gigaxonin) | Protein binding | -1.41 |
| BOTL0100005XF07R | SFPQ | Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) | DNA, RNA, nucleotide and protein binding | -1.67 |
| BOTL0100007_C06 | NRM | Nurim | Nuclear envelope membrane protein | -3.07 |
| BOTL0100013_F01 | - | Unknown | Unknown – limited similarity to Formin 2 | -1.59 |
| Fibroblast growth factor receptor 1 | FGFR1 | Fibroblast growth factor receptor 1 | ATP, nucleotide and protein binding. Receptor and tranferase activity. | -2.77 |
| NBFGC_BE479784 | TBK1 | TANK-binding kinase 1 | ATP and nucleotide binding. Protein kinase and signal transducer activity. | -1.63 |
| NBFGC_BE682784 | 28S | 28S ribosomal RNA gene | Protein biosynthesis | 1.52 |
| NBFGC_BF076990 | GPR98 | G protein-coupled receptor 98 | G-protein coupled receptor activity, calcium ion binding | 2.07 |
| Neuropilin 1 (NRP1) | NRP1 | Neuropilin 1 | Receptor activity, vascular endothelial growth factor receptor activity | -2.98 |
Clone IDs were obtained from the Center for Animal Functional Genomics (CAFG) website [51].