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Expression of the transgene villin-Cdx1 transgene was lost in the adenomas elicited by AOM/DSS treatment. (A) Sections were obtained from the AOM/DSS polyps and were immunohistochemically stained for Cdx1, the Myc-tagged Cdx1, or Cdx2 proteins. A region of normal epithelium was included for comparison. (B) Staining for β-catenin and villin expression in the polyps from transgenic mice. Insets: higher magnification photo of neoplastic cells.
