Figure 1.

Topical treatment with a gomesin-containing cream delayed subcutaneous tumor development and increased the time of living animals with tumors below the maximum allowed size. B16F10-Nex2 murine melanoma cells (10⁵ per animal) were injected subcutaneously into the hair-free flank of C57BL/6 male mice. Animals were treated topically with a Gm-containing cream (white circles, n = 10) or a control cream (black circles, n = 5), as described in Materials and Methods. (A) Individual tumor volumes. (B) Treated and control mice bearing tumors bellow 3000 mm³ after different times of tumor implantation. Log rank test, P < .01.