Table 4.

Univariate analysis of prognostic factors in CCG-2961

	N	EFS			OS
		5 years	HR	P	5 years	HR	P
Age, y
Less than 2	193	39 ± 7	1.37	.013	56 ± 7	1.11	.477
2 to less than 10	275	46 ± 6	1	—	58 ± 6	1	—
10 to less than 16	310	42 ± 6	1.17	.180	50 ± 6	1.27	.058
16 or over	123	34 ± 9	1.51	.004	40 ± 9	1.74	<.001
WBC, × 109/L
Less than 50	639	45 ± 4	1	—	56 ± 4	1	—
50 to less than 100	118	33 ± 9	1.31	.036	47 ± 10	1.31	.059
100 or more	143	32 ± 8	1.52	<.001	41 ± 8	1.57	<.001
Race
White	583	44 ± 4	1	—	56 ± 4	1	—
Black	84	30 ± 10	1.44	.012	37 ± 11	1.60	.002
Hispanic	157	39 ± 8	1.20	.131	47 ± 8	1.34	.024
Asian	26	50 ± 19	0.89	.670	54 ± 19	1.11	.726
Other	34	39 ± 17	1.26	.310	51 ± 18	1.20	.501
Cytogenetic risk
Standard	396	36 ± 5	1	—	47∥± 5	1	—
Favorable*	138	61 ± 8	0.49	<.001	72 ± 8	0.45	<.001
Unfavorable†	290	29 ± 17	1.40	.149	39 ± 19	1.35	.237
Body mass index
Middle weight	570	45 ± 4	1	—	54 ± 4	1	—
Less than10% for age	83	35 ± 11	1.41	.023	51 ± 11	1.24	.218
More than 95% for age	114	34 ± 9	1.35	.022	44 ± 10	1.46	.007
Early response, day 14+1 marrow	770	—	1.29	.075	—	1.25	.158

Data in “5 year” columns are percentages.

HR indicates hazard ratio; and —, not applicable.

*Favorable cytogenetic risk is t(8;21) and inv (16).

†Unfavorable is del(7), 7q−, del(5), 5q−, and more than 3 nonrandom abnormalities.

‡The day 14 marrow assessment was for less than 5% blasts; it is a time-dependent variable.