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. 2008 Feb 1;118(3):1027–1039. doi: 10.1172/JCI32020

Figure 8. IL-7 treatment attenuates clonal downsizing of TCR transgenic CD8 T cells and enhances CD8 T cell memory.

Figure 8

Naive Thy1.1+ve P14 CD8 T cells were adoptively transferred into congenic Thy1.2/C57BL/6 mice and infected with LCMV. Between days 7 and 14 after infection, mice received daily injections of IL-7 or PBS. On days 15 (A) and 55 (B) after infection, the number of TCR transgenic P14 CD8 T cells in the spleen was quantitated by staining splenocytes with anti-Thy1.1, Db/GP33 tetramers, and anti-CD8. Each symbol point represents data from an individual mouse.