Table 2.
Association between NAT1 and NAT2 genotypes and risk of pancreatic cancer
| Genotype | Patients, n (%) | Controls, n (%) | OR* (95% CI) | Acetylator phenotype |
|---|---|---|---|---|
| NAT1*4/*4 | 291 (55.8) | 337 (58.4) | 1.00 | Reference |
| NAT1*4/*other† | 13 (2.5) | 16 (2.8) | 1.04 (0.45-2.43) | |
| NAT1*10/*other† | 142 (27.2) | 154 (26.7) | 1.05 (0.76-1.46) | |
| NAT1*11/*other† | 24 (4.6) | 18 (3.1) | 1.19 (0.56-2.54) | |
| NAT1*10/*10 + NAT1*10/*11 | 31 (5.9) | 23 (4.0) | 1.97 (1.02-3.82) | Rapid |
| NAT1*4/*3 | 21 (4.0) | 29 (5.0) | 0.79 (0.39-1.59) | Reference |
| NAT1 other | 487 (94.0) | 553 (96.0) | 1.00 | |
| NAT1*10/*10 + NAT1*10/*11 | 31 (6.0) | 23 (4.0) | 1.96 (1.03-3.73) | Rapid |
| NAT2*4/*4 | 31 (5.9) | 27 (4.8) | 1.00 | Rapid |
| NAT2*4/*5B | 111 (21.1) | 125 (22.2) | 0.59 (0.30-1.16) | Intermediate |
| NAT2*4/*6A | 65 (12.4) | 71 (12.6) | 0.61 (0.30-1.27) | Intermediate |
| NAT2*4/*5‡ | 9 (1.7) | 5 (0.9) | 1.75 (0.36-8.43) | Intermediate |
| Other NAT2 intermediate acetylator genotype‡ | 10 (1.9) | 10 (1.8) | 0.85 (0.27-2.69) | Intermediate |
| NAT2*5B/*6A | 118 (22.4) | 124 (22.0) | 0.72 (0.36-1.42) | Slow |
| NAT2*5B/*5B | 83 (15.8) | 104 (18.4) | 0.67 (0.33-1.34) | Slow |
| NAT2*6A/*6A | 37 (7.0) | 45 (8.0) | 0.64 (0.29-1.40) | Slow |
| NAT2*5A/*5B | 18 (3.4) | 14 (2.5) | 1.07 (0.39-3.00) | Slow |
| NAT2*5B/*7B | 12 (2.3) | 11 (1.9) | 0.77 (0.25-2.39) | Slow |
| NAT2*6A/*7B | 12 (2.3) | 9 (1.6) | 0.80 (0.24-2.67) | Slow |
| NAT2*5/*5 and NAT2*5/*6‡ | 8 (1.7) | 9 (1.6) | 0.87 (0.27-2.81) | Slow |
| NAT2*5A/*6A‡ | 6 (1.1) | 9 (1.6) | 0.69 (0.19-2.57) | Slow |
| Other NAT2 slow acetylator genotype‡ | 5 (0.9) | 1 (0.2) | 3.91 (0.39-38.9) | Slow |
| NAT2 other | 349 (66.4) | 371 (65.8) | 1.00 | |
| NAT2*6A/any* | 177 (33.6) | 193 (34.2) | 0.97 (0.75-1.26) | Slow |
*
OR adjusted for age, sex, pack-year of smoking (categorical), history of diabetes, and NAT2 genotype (slow versus other, for the NAT1 analysis) or NAT1 genotype (rapid versus other, for the NAT2 analysis).
†
NAT1*4/other comprises *4/*14B, *4/*15, *4/*17, *4/*22, *4/*14A, and *10/*14B; *10/other comprises *4/*10, *3/*10, and *10/*14A; *11/other comprises *4/*11A or *3/*11B, *4/*11B, *3/*11A, and *11B/*22.
‡
Intermediate comprises *4/*6B, *4/*7B, *5B/*12A, *5B/13, 5B/*14B, *6A/*12A, and *6A/*13; *5 comprises *5A and *5C; *5/*5 and *5/*6 comprise *5B/*5C, *5C/*5C, *5B/*6C, and *5C/*6A; other slow comprises *5A/*7B, *5B/*13, *6A/*6C, and *7B/*7B.