Table 5.
Joint effect of NAT2 acetylation genotype and history of diabetes in modifying risk of pancreatic cancer
| NAT2 acetylation genotype | History of diabetes | Patients (n = 526) |
Controls (n = 564) |
OR* (95% CI) | Ptrend† | Pinteraction‡ |
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
| All study participants | ||||||
| All other; | No | 285 (54.2) | 335 (59.4) | 1.00 | ||
| *6A/*5 + *6A/*6 + *6A/*7 | No | 134 (25.5) | 178 (31.6) | 0.90 (0.68-1.19) | ||
| All other; | Yes | 64 (12.2) | 36 (6.4) | 2.04 (1.31-3.21) | ||
| *6A/*5 + *6A/*6 + *6A/*7 | Yes | 43 (8.1) | 15 (2.6) | 3.51 (1.90-6.50) | <0.001 | 0.12 |
| Rapid/intermediate | No | 196 (36.3) | 215 (38.1) | 1.00 | ||
| Slow | No | 228 (43.4) | 298 (52.8) | 0.87 (0.67-1.14) | ||
| Rapid/intermediate | Yes | 35 (6.6) | 23 (4.1) | 1.53 (0.86-2.73) | ||
| Slow | Yes | 72 (13.7) | 28 (5.0) | 3.10 (1.90-5.05) | <0.001 | 0.07 |
| Never smokers | ||||||
| All others | No | 114 (52.8) | 161 (57.3) | 1.00 | ||
| *6A/*5 + *6A/*6 + *6A/*7 | No | 61 (28.2) | 97 (34.5) | 0.92 (0.61-1.40) | ||
| All others | Yes | 27 (12.5) | 15 (5.3) | 2.38 (1.19-4.75) | ||
| *6A/*5 + *6A/*6 + *6A/*7 | Yes | 14 (6.5) | 8 (2.8) | 2.66 (1.07-6.59) | 0.01 | 0.88 |
| Rapid/intermediate | No | 85 (39.4) | 101 (35.9) | 1.00 | ||
| Slow | No | 90 (41.7) | 157 (55.9) | 0.71 (0.48-1.06) | ||
| Rapid/intermediate | Yes | 14 (6.5) | 7 (2.4) | 2.14 (0.81-5.68) | ||
| Slow | Yes | 27 (12.5) | 16 (5.7) | 2.07 (1.03-3.99) | 0.06 | 0.72 |
| Ever smokers | ||||||
| All others | No | 171 (55.2) | 171 (61.0) | 1.00 | ||
| *6A/*5 + *6A/*6 + *6A/*7 | No | 73 (23.6) | 81 (29.0) | 0.88 (0.59-1.30) | ||
| All others | Yes | 37 (11.9) | 21 (7.5) | 1.89 (1.04-3.42) | ||
| *6A/*5 + *6A/*6 + *6A/*7 | Yes | 29 (9.3) | 7 (2.5) | 4.59 (1.94-10.88) | <0.001 | 0.07 |
| Rapid/intermediate | No | 106 (34.2) | 112 (40.0) | 1.00 | ||
| Slow | No | 138 (44.5) | 140 (50.0) | 1.05 (0.73-1.52) | ||
| Rapid/intermediate | Yes | 21 (6.8) | 16 (5.7) | 1.42 (0.68-2.95) | ||
| Slow | Yes | 45 (14.5) | 12 (4.3) | 4.65 (2.29-9.42) | <0.001 | 0.04 |
*
OR (95% CI) adjusted for age, sex, and NAT1 genotype (rapid versus others). Smoking pack-year (light versus heavy) was additionally adjusted for ever smokers. Smoking pack-year (never, light, and heavy) was additionally adjusted for all participants.
†
P value for the trend test. Score test was used to test the linear trend by treating interaction term as the continuous variable.
‡
P value for the likelihood ratio test.