TABLE 1. Cognitive measures observed in Tg2576 compared to the WT.

	Y-maze	T-maze	MWM I	MWM II	RAM	RAWM I	RAWM II	Visual platform	Circular holeboard
Hsiao, 1996	↔3 mos ↓10 mos		↔2, 6 mos* ↓ 9-10 mos ↓ 12-15 mos	↓ 10 mos				↔ 9-10mos**
Pompl, 1999									↔7 mos (learning), ↓ reversal learning
Chapman, 1999		↔2 mos ↓10 mos ↓16 mos
Arendash, 2001 (Pre-vaccination)	↔5-7mos		↔5-7 mos			↓15mos (IgG vaccinated)	↔5-7mos		↔5-7 mos
King & Arendash, 2002	↓3 mos ↔9 mos ↔ 14 mos ↓19 mos		↔3 mos ↔9 mos ↔14 mos ↔19 mos	↔3 mos ↔9 mos ↔14mos ↔19 mos				↓3 mos ↓9 mos ↓14 mos ↓19 mos	↔3 mos ↔9 mos ↔14 mos ↔19 mos
Sigurdsson, 2004 (IgG vaccinated)					↓19 mos
Ognibene, 2005	↓7-12 mos	↑7-12 mos***

↓=performed worse than WT

↑=performed better than WT

↔=no different than WT

Y-maze: tendency to alternate arm choice, T-maze: choice of novel arm, MWM I: escape latency, MWM II: time spent in target quadrant after platform removal, RAM: errors, RAWM I: latency, RAWM II: errors

^*6month Tg animals differed from WT on last day of testing only

^**10 mos Tg animals differed from WT on days 2 and 4, but no differences were observed on day 1

^***elevated plus maze measure of exploration of arms