Table 2.
T + DES-Induced VP Dysplasia Panel: Genes Whose Expression Selectively Changed following T + DES Treatment in the VPs Harboring Dysplasia, but not in the LPs.
| Gene Names | Locus ID | Symbol | Fold Changes | Functions |
| glutathione peroxidase 3* | 64317 | GPX3 | 17.188 | Cellular development; cellular growth and proliferation; post-translational modification; protein synthesis |
| ferritin, heavy polypeptide 1* | 25319 | FTH1 | 6.304 | Cell death; cell morphology; cellular growth and proliferation; DNA replication, recombination, and repair; free radical scavenging; post-translational modification |
| protein phosphatase 2a, catalytic subunit, alpha isoform* | 24672 | PPP2CA | 3.388 | Biomolecule metabolism; cell death; cellular growth and proliferation; post-translational modification |
| monocarboxylate transporter* | 80878 | SLC16A3 | 2.263 | Others/unclassified |
| nuclease-sensitive element binding protein 1* | 29206 | NSEP1 | 1.898 | Cell death; gene transcription |
| thymopoietin* | 25359 | TMPO | 1.814 | Cell cycle; DNA replication, recombination, and repair; gene transcription |
| homeo box A1* | 25607 | HOXA1 | 1.586 | Cell death; cellular development; cellular movement; gene transcription |
| cystatin C* | 25307 | CST3 | 1.585 | Cell death; cellular development; cellular growth and proliferation |
| thyroid hormone receptor alpha* | 81812 | THRA | 1.583 | Cell death; cell morphology; cellular development; free radical scavenging; gene transcription |
| tubulin, alpha 1* | 64158 | TUBA1A | 1.580 | Inflammation |
| phospholipase C, delta 1* | 24655 | PLCD1 | 1.532 | Cellular growth and proliferation |
| glutamate receptor, metabotropic 7* | 81672 | GRM7 | 1.481 | Cell signaling |
| potassium voltage-gated channel, subfamily H (eag-related),member 7* | 170739 | KCNH7 | 1.481 | Others/unclassified |
| plasminogen activator, urokinase* | 25619 | PLAU | 1.461 | Cell cycle; cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; inflammation |
| vesicle-associated membrane protein 2 | 24803 | VAMP2 | 1.452 | Cell signaling; cellular assembly and organization; cellular movement; molecular transport |
| glyceraldehyde-3-phosphate dehydrogenase* | 24383 | GAPDH | 1.401 | Others/unclassified |
| protein phosphatase 1F (PP2C domain containing)* | 287931 | PPM1F | 1.392 | Biomolecule metabolism; cell death; post-translational modification |
| tumor protein p53* | 24842 | TP53 | 1.379 | Cell cycle; cell death; cell morphology; cell signaling; cellular assembly and; organization; cellular development; cellular growth and proliferation; cellular movement; cellular response to therapeutics; DNA replication, recombination, and repair; free radical scavenging; gene transcription; inflammation; post-translational modification; protein synthesis |
| opioid receptor, mu 1* | 25601 | OPRM1 | 1.375 | Cell death; cell signaling; cellular growth and proliferation; cellular movement; inflammation |
| calcitonin/calcitonin-related polypeptide, alpha* | 24241 | CALCA | 1.361 | Cell cycle; cell death; cell morphology; cell signaling; cellular development; cellular growth and proliferation; cellular movement; DNA replication, recombination, and repair; gene transcription; inflammation |
| testis-specific protein* | 192229 | C3ORF34 | 1.357 | Others/unclassified |
| eukaryotic translation initiation factor 2B, subunit 2 beta* | 84005 | EIF2B2 | 1.334 | Cellular development; cellular growth and proliferation |
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide* | 25576 | YWHAH | 1.333 | Cellular assembly and organization; gene transcription |
| glucagon-like peptide 1 receptor | 25051 | GLP1R | 1.328 | Cell death; gene transcription; inflammation |
| transient receptor potential cation channel, subfamily C, member 2* | 64573 | TRPC2 | 1.322 | Others/unclassified |
| dopamine receptor 4* | 25432 | DRD4 | 1.311 | Cell signaling |
| early growth response 3* | 25148 | EGR3 | 1.289 | Cell death; cell signaling; cellular development; cellular growth and proliferation; gene transcription |
| glutamate receptor, ionotropic, NMDA2B* | 24410 | GRIN2B | 1.248 | Cell morphology; cell signaling |
| chemokine (C-X-C motif) ligand 5* | 60665 | CXCL6 | 1.236 | Cell signaling; cellular movement |
| myosin IC | 65261 | MYO1C | 1.190 | Cell morphology |
| breast cancer anti-estrogen resistance 1 | 25414 | BCAR1 | 1.190 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement |
| aryl hydrocarbon receptor nuclear translocator 2 | 25243 | ARNT2 | 1.172 | Gene transcription |
| CCAAT/enhancer binding protein (C/EBP), delta | 25695 | CEBPD | 1.151 | Cell cycle; cell death; cellular development; cellular growth and proliferation; gene transcription; inflammation; biomolecule metabolism; molecular transport |
| CTD-binding SR-like rA1 | 56081 | SR-A1 | 1.148 | Others/unclassified |
| ADP-ribosylation factor 6 | 79121 | ARF6 | 1.142 | Cell death; cell morphology; cellular assembly and organization; cellular movement |
| calmodulin 3 | 24244 | CALM3 | 1.138 | Cell death; cellular growth and proliferation; post-translational modification |
| synaptotagmin 3 | 25731 | SYT3 | 1.115 | Cell signaling; cellular assembly and organization; cellular movement; molecular transport |
| dynein, cytoplasmic, light chain 1 | 58945 | DYNLL1 | 1.090 | Cell death; cell morphology; cellular assembly and organization |
| MAD homolog 7 (Drosophila) | 81516 | SMAD7 | 1.062 | Cell cycle; cell death; cell morphology; cellular development; cellular growth and proliferation; cellular movement; gene transcription |
| v-maf musculoaponeurotic fibrosarcom oncogene family, protein B (avian) | 54264 | MAFB | 1.062 | Cell death; cellular development; cellular movement; gene transcription |
| calmodulin 3 | 24244 | CALM3 | 1.060 | Cellular growth and proliferation; post-translational modification |
| thymosin, beta 10 | 50665 | TMSB10 | 1.059 | Cell death; cellular assembly and organization; cellular growth and proliferation |
| aldehyde dehydrogenase family 1, subfamily A2 | 116676 | ALDH1A2 | 1.035 | Cell death; cellular development; cellular growth and proliferation |
| syntaxin 1B2 | 24923 | STX1B2 | 1.032 | Others/unclassified |
| aldolase A | 24189 | ALDOA | -1.013 | Others/unclassified |
| prosaposin | 25524 | PSAP | -1.031 | Cell cycle; cell death; cellular growth and proliferation; biomolecule metabolism; molecular transport; post-translational modification |
| vesicle-associated membrane protein 2 | 24803 | VAMP2 | -1.031 | Cell death; cell signaling; cellular assembly and organization; cellular movement; molecular transport |
| Rous sarcoma oncogene | 83805 | SRC | -1.070 | Biomolecule metabolism; cell cycle; cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; DNA replication, recombination, and repair; gene transcription; molecular transport; post-translational modification |
| acetylcholinesterase | 83817 | ACHE | -1.072 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; DNA replication, recombination, and repair; post-translational modification; protein synthesis |
| Max interacting protein 1 | 25701 | MXI1 | -1.120 | Cell morphology; cellular growth and proliferation; gene transcription |
| betacellulin | 64022 | BTC | -1.137 | Cell cycle; cell death; cell signaling; cellular development; cellular growth and proliferation; cellular movement; DNA replication, recombination, and repair |
| argininosuccinate synthetase | 25698 | ASS1 | -1.165 | Others/unclassified |
| nuclear receptor subfamily 1, group D, member 2 | 259241 | NR1D2 | -1.170 | Gene transcription |
| stannin | 29140 | SNN | -1.242 | Cell death |
| phosphatase and tensin homolog* | 50557 | PTEN | -1.272 | Cell cycle; cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; gene transcription inflammation; biomolecule metabolism; molecular transport; post-translational modification |
| solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7* | 116638 | SLC17A7 | -1.287 | Cell signaling |
| carnitine palmitoyltransferase 1, liver* | 25757 | CPT1A | -1.291 | Biomolecule metabolism |
| isopentenyl-diphosphate delta isomerase* | 89784 | IDI1 | -1.294 | Others/unclassified |
| LIM homeobox protein 5 | 124451 | LHX5 | -1.317 | Others/unclassified |
| calpain, small subunit 1* | 29156 | CAPNS1 | -1.318 | Cell death; cellular assembly and organization; cellular growth and proliferation; cellular movement |
| filaggrin | 24641 | FLG | -1.325 | Cellular assembly and organization |
| microsomal glutathione S-transferase 1 | 171341 | MGST1 | -1.329 | Biomolecule metabolism |
| protein tyrosine phosphatase, nonreceptor type substrate 1* | 25528 | SIRPA | -1.330 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; gene transcription; inflammation |
| neurofibromatosis 2 | 25744 | NF2 | -1.333 | Cell death; cellular growth and proliferation; cellular movement |
| Notch gene homolog 3 (Drosophila)* | 56761 | NOTCH3 | -1.335 | Cellular development; gene transcription |
| killer cell lectin-like receptor subfamily B member 1B* | 25192 | KLRB1 | -1.338 | Cell death |
| basic transcription element binding protein 1* | 117560 | KLF9 | -1.339 | Gene transcription |
| regulating synaptic membrane exocytosis 1* | 84556 | RIMS1 | -1.353 | Cell morphology; cell signaling; cellular assembly and organization; cellular movement; molecular transport |
| transglutaminase 1* | 60335 | TGM1 | -1.376 | Biomolecule metabolism; cell death; cellular development; post-translational modification |
| translocase of inner mitochondrial membrane 23 homolog (yeast)* | 54312 | IMM23 | -1.393 | Others/unclassified |
| lysozyme | 25211 | LYZ | -1.399 | Others/unclassified |
| solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11* | 64201 | SLC25A11 | -1.407 | Others/unclassified |
| hydroxysteroid 11-beta dehydrogenase 1* | 25116 | HSD11B1 | -1.407 | Cellular development; cellular growth and proliferation |
| potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3* | 54263 | KCNN3 | -1.412 | Cell signaling |
| B-cell leukemia/lymphoma 2* | 24224 | BCL2 | -1.413 | Cell cycle; cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; cellular response to therapeutics; DNA replication, recombination, and repair; biomolecule metabolism; gene transcription; inflammation; molecular transport; post-translational modification |
| hyperpolarization-activated, cyclic nucleotide-gated K+ 4* | 59266 | HCN4 | -1.415 | Cell signaling |
| perforin 1 (pore-forming protein)* | 50669 | PRF1 | -1.417 | Cell death; cell morphology; cell signaling; DNA replication, recombination, and repair; inflammation |
| calcitonin/calcitonin-related polypeptide, alpha* | 24241 | CALCA | -1.433 | Cell morphology; cell signaling; cellular development; cellular growth and proliferation; cellular movement; DNA replication, recombination, and repair; gene transcription; inflammation |
| nuclear RNA export factor 1* | 59087 | NXF1 | -1.436 | Protein synthesis |
| fibroblast growth factor 14* | 63851 | FGF14 | -1.439 | Others/unclassified |
| solute carrier family 7 (cationic amino acid transporter,y+ system), member 3* | 29485 | SLC7A3 | -1.455 | Others/unclassified |
| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1* | 171375 | ATP5F1 | -1.456 | Cellular growth and proliferation |
| septin 3* | 56003 | SEPT3 | -1.468 | Others/unclassified |
| cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)* | 54239 | CHRNB2 | -1.469 | Cell signaling |
| wild-type p53-induced gene 1* | 64394 | ZMAT3 | -1.480 | Cell death; cellular growth and proliferation; DNA replication, recombination, and repair |
| glutamate receptor, ionotropic, kainate 4* | 24406 | GRIK4 | -1.482 | Cell signaling |
| Kruppel-like factor 15* | 85497 | KLF15 | -1.488 | Gene transcription |
| aquaporin 6* | 29170 | AQP6 | -1.496 | Others/unclassified |
| unc-5 homolog A (C. elegans)* | 60629 | UNC5A | -1.498 | Cell death |
| integrin beta 4* | 25724 | ITGB4 | -1.502 | Cell death; cell morphology; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; gene transcription |
| peptidylprolyl isomerase A* | 25518 | PPIA | -1.526 | Cell death; cellular development; cellular growth and proliferation; cellular movement; DNA replication, recombination, and repair; inflammation; post-translational modification |
| FXYD domain-containing ion transport regulator 6* | 63847 | FXYD6 | -1.562 | Others/unclassified |
| ribosomal protein L37* | 81770 | RPL37 | -1.579 | Others/unclassified |
| RT1 class II, locus Da* | 294269 | HLA-DRA | -1.580 | Cell signaling; inflammation |
| FK506 binding protein 12-rapamycin-associated protein 1* | 56718 | FRAP1 | -1.596 | Biomolecule metabolism; cell cycle; cell death; cell morphology; cell signaling; cellular development; cellular growth and proliferation; cellular movement; gene transcription; inflammation; post-translational modification; protein synthesis |
| eukaryotic translation elongation factor 1 alpha 1* | 171361 | EEF1A1 | -1.618 | Cell death; protein synthesis |
| glutathione S-transferase theta 1* | 25260 | GSTT1 | -1.622 | Biomolecule metabolism |
| solute carrier family 4, member 1* | 24779 | SLC4A1 | -1.630 | Cell death; cellular growth and proliferation |
| fibroblast growth factor 17* | 29368 | FGF17 | -1.642 | Cellular growth and proliferation |
| forkhead box M1* | 58921 | FOXM1 | -1.646 | Cell cycle; cell death; cell morphology; cellular growth and proliferation; gene transcription |
| ATPase, class II, type 9A* | 84011 | ATP9A | -1.649 | Others/unclassified |
| phosphorylase kinase, gamma 2 (testis)* | 140671 | PHKG2 | -1.679 | Biomolecule metabolism; post-translational modification |
| arrestin, beta 1* | 25387 | ARRB1 | -1.683 | Cellular movement |
| rhoB gene* | 64373 | RHOB | -1.684 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; gene transcription |
| par-3 (partitioning defective 3) homolog (C. elegans)* | 81918 | PARD3 | -1.686 | Cell morphology; cell signaling; cellular assembly and organization; cellular development; gene transcription |
| ribosomal protein L21* | 79449 | RPL21 | -1.687 | Others/unclassified |
| RAS protein-specific guanine nucleotide-releasing factor 1* | 192213 | RASGRF1 | -1.715 | Cell morphology; cell signaling; cellular growth and proliferation; gene transcription |
| acetylcholinesterase* | 83817 | ACHE | -1.741 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; DNA replication, recombination, and repair; post-translational modification; protein synthesis |
| ribosomal protein L18* | 81766 | RPL18 | -1.741 | Others/unclassified |
| granzyme M (lymphocyte met-ase 1)* | 29252 | GZMM | -1.745 | Cell death |
| Bcl2-associated X protein* | 24887 | BAX | -1.746 | Cell cycle; cell death; cell morphology; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular response to therapeutics; DNA replication, recombination, and repair; free radical scavenging; inflammation; biomolecule metabolism; molecular transport; protein synthesis |
| legumain* | 63865 | LGMN | -1.749 | Cellular movement |
| RAB6A, member RAS oncogene family* | 84379 | RAB6A | -1.752 | Cellular assembly and organization |
| matrix metalloproteinase 16* | 65205 | MMP16 | -1.763 | Cellular movement; inflammation |
| olfactory receptor 226* | 65140 | OR6A2 | -1.770 | Others/unclassified |
| mitogen-activated protein kinase 14* | 81649 | MAPK14 | -1.775 | Biomolecule metabolism; cell cycle; cell death; cell morphology; cellular development; cellular growth and proliferation; cellular movement; gene transcription; inflammation; post-translational modification |
| c-mer protooncogene tyrosine kinase* | 65037 | MERTK | -1.780 | Biomolecule metabolism; cell death; cell morphology; cell signaling; cellular development; cellular growth and proliferation; post-translational modification |
| clathrin, heavy polypeptide (Hc)* | 54241 | CLTC | -1.786 | Cell morphology; cellular growth and proliferation |
| transient receptor potential cation channel, subfamily C, member 4* | 84494 | TRPC4 | -1.793 | Others/unclassified |
| carnitine palmitoyltransferase 1b* | 25756 | CPT1B | -1.795 | Biomolecule metabolism |
| PDZ and LIM domain 1 (elfin)* | 54133 | PDLIM1 | -1.796 | Gene transcription |
| fatty acid amide hydrolase* | 29347 | FAAH | -1.798 | Cell death; inflammation |
| fatty acid binding protein 4, adipocyte* | 79451 | FABP4 | -1.820 | Gene transcription |
| protein tyrosine phosphatase, nonreceptor type 12* | 117255 | PTPN12 | -1.826 | Biomolecule metabolism; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular movement; post-translational modification |
| potassium voltage-gated channel, Shab-related subfamily, member 2* | 117105 | KCNB2 | -1.834 | Others/unclassified |
| glutathione S-transferase, pi 2* | 29438 | GSTP1 | -1.856 | Cell death; cellular growth and proliferation; biomolecule metabolism; gene transcription |
| Fc receptor, IgG, alpha chain transporter* | 29558 | FCGRT | -1.870 | Cell signaling; molecular transport |
| voltage-gated channel like 1* | 266760 | VGCNL1 | -1.871 | Others/unclassified |
| prostaglandin D2 synthase* | 25526 | PTGDS | -1.888 | Cell death; cell morphology |
| MAP-kinase activating death domain* | 94193 | MADD | -1.934 | Cell death; cellular growth and proliferation |
| neogenin* | 81735 | NEO1 | -1.935 | Cellular growth and proliferation; cellular movement; gene transcription |
| calbindin 1* | 83839 | CALB1 | -1.950 | Cell death; cell morphology; cell signaling |
| guanylate cyclase 2e* | 79222 | GUCY2D | -1.957 | Others/unclassified |
| adrenal secretory serine protease precursor* | 64565 | TMPRSS11D | -1.971 | Others/unclassified |
| ubc2e ubiquitin-conjugating enzyme* | 641452 | Ube2d2 | -1.986 | Others/unclassified |
| neuroblastoma, suppression of tumorigenicity 1* | 50594 | NBL1 | -2.003 | Cellular movement |
| collagen, type 1, alpha 1* | 29393 | COL1A1 | -2.023 | Cell morphology; cellular growth and proliferation; cellular movement |
| homeodomain interacting protein kinase 3* | 83617 | HIPK3 | -2.034 | Biomolecule metabolism; cell signaling; post-translational modification |
| intercellular adhesion molecule 1* | 25464 | ICAM1 | -2.052 | Cell death; cell morphology; cell signaling; cellular development; cellular growth and proliferation; cellular movement; inflammation |
| cyclin-dependent kinase 5* | 140908 | CDK5 | -2.134 | Biomolecule metabolism; cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; molecular transport; post-translational modification |
| ATPase, Cu2+ transporting, beta polypeptide* | 24218 | ATP7B | -2.137 | Cell death |
| Jun D protooncogene* | 24518 | JUND | -2.159 | Cell death; cell morphology; cellular growth and proliferation; gene transcription |
| neurexophilin 3* | 59315 | NXPH3 | -2.168 | Others/unclassified |
| heterogeneous nuclear ribonucleoprotein methyltransferase-like 3 (S. cerevisiae)* | 89820 | PRMT3 | -2.171 | Biomolecule metabolism; post-translational modification |
| midline 1* | 54252 | MID1 | -2.180 | Cellular assembly and; organization |
| ATP-binding cassette, subfamily C (CFTR/MRP), member 1* | 24565 | ABCC1 | -2.191 | Cell death; cellular movement; inflammation; biomolecule metabolism; molecular transport |
| prothymosin alpha* | 29222 | PTMA | -2.313 | Cell cycle; cell death; cellular development; cellular growth and proliferation; gene transcription |
| ubiquilin 1* | 114590 | UBQLN1 | -2.322 | Others/unclassified |
| similar to Leydig cell tumor 10 kDa protein* | 288913 | C19ORF53 | -2.346 | Others/unclassified |
| Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein* | 25587 | ID2 | -2.357 | Cell cycle; cell death; cell morphology; cellular development; cellular growth and proliferation; cellular movement; gene transcription |
| lectin, galactose binding, soluble 1* | 56646 | LGALS1 | -2.385 | Cell cycle; cell death; cell morphology; cellular development; cellular growth and proliferation; cellular movement gene transcription; inflammation; post-translational modification |
| calreticulin* | 64202 | CALR | -2.401 | Cell cycle; cell death; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement; gene transcription; post-translational modification |
| carbonic anhydrase 5* | 54233 | CA5A | -2.427 | Inflammation |
| mitogen-activated protein kinase 13* | 29513 | MAPK13 | -2.438 | Cell death; cell morphology; gene transcription; inflammation |
| cytochrome P450, family 19, subfamily a, polypeptide 1* | 25147 | CYP19A1 | -2.440 | Cell death; cell morphology; cellular development; cellular growth and proliferation; cellular movement; gene transcription; biomolecule metabolism |
| nucleobindin 1* | 84595 | NUCB1 | -2.513 | Others/unclassified |
| tropomodulin 2* | 58814 | TMOD2 | -2.563 | Cell signaling; cellular assembly and organization |
| apolipoprotein B editing complex 1* | 25383 | APOBEC1 | -2.655 | Others/unclassified |
| solute carrier family 7 (cationic amino acid transporter, y+ system), member 7* | 83509 | SLC7A7 | -2.720 | Cell signaling; cellular growth and proliferation |
| hsp70-interacting protein* | 246146 | HSPBP1 | -2.772 | Post-translational modification |
| Rsec5 protein* | 171455 | EXOC2 | -2.779 | Cell signaling; molecular transport |
| MAD homolog 9 (Drosophila)* | 85435 | SMAD9 | -2.815 | Others/unclassified |
| ERM-binding phosphoprotein* | 59114 | SLC9A3R1 | -2.851 | Cell signaling; cellular growth and proliferation |
| low-density lipoprotein receptor-related protein 3* | 89787 | LRP3 | -2.869 | Others/unclassified |
| Rab geranylgeranyl transferase, a subunit* | 58983 | RABGGTA | -2.890 | Biomolecule metabolism; post-translational modification |
| cadherin EGF LAG seven-pass G-type receptor 2* | 83465 | CELSR2 | -2.923 | Others/unclassified |
| tropomyosin 4* | 24852 | TPM4 | -3.019 | Cellular movement |
| cytochrome P450, family 2, subfamily e, polypeptide 1* | 25086 | CYP2E1 | -3.161 | Cell death; biomolecule metabolism |
| CEA-related cell adhesion molecule 9* | 116711 | CEACAM9 | -3.207 | Others/unclassified |
| discoidin domain receptor family, member 2* | 83573 | DDR2 | -3.253 | Others/unclassified |
| phosphoglucomutase 1* | 24645 | PGM1 | -3.308 | Others/unclassified |
| gamma-glutamyl carboxylase* | 81716 | GGCX | -3.455 | Post-translational modification |
| Cplx1 complexin 1* | 64832 | CPLX1 | -3.464 | Cell signaling; cellular assembly; and organization; cellular movement; molecular transport |
| septin 9* | 83788 | SEPT9 | -3.781 | Cell cycle; protein synthesis |
| matrix metallopeptidase 8* | 63849 | MMP8 | -3.785 | Cell death, cellular movement |
| thyroid hormone receptor interactor 10* | 116717 | TRIP10 | -4.232 | Cell death |
| carboxylesterase 3* | 113902 | CES1 | -4.325 | Others/unclassified |
| cyclin-dependent kinase 2* | 362817 | CDK2 | -4.458 | Biomolecule metabolism; cell cycle; cell death; cell morphology; cellular development; cellular growth and proliferation; DNA replication, recombination, and repair; gene transcription; post-translational modification |
| monoamine oxidase B* | 25750 | MAOB | -4.873 | Cell death |
| solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12* | 50676 | SLC6A12 | -5.287 | Others/unclassified |
| peroxiredoxin 1* | 117254 | PRDX1 | -5.360 | Cell death; cell morphology; cellular growth and proliferation; gene transcription; post-translational modification |
| ADP-ribosylation factor 4* | 79120 | ARF4 | -5.374 | Others/unclassified |
| glypican 3* | 25236 | GPC3 | -5.638 | Cell death; cellular growth and proliferation |
| protein kinase C, delta binding protein* | 85332 | PRKCDBP | -6.059 | Others/unclassified |
| cd86 antigen* | 56822 | CD86 | -6.118 | Cell signaling; cellular development; cellular growth and proliferation; cellular movement; gene transcription; inflammation |
| Sjogren syndrome antigen B* | 81783 | SSB | -6.131 | Gene transcription; protein synthesis |
| secretoglobin, family 2A, member 1* | 25010 | PSBP1 | -6.227 | Others/unclassified |
| procollagen, type I, alpha 2* | 84352 | COL1A2 | -7.076 | Cell morphology |
| A kinase (PRKA) anchor protein 1* | 114124 | AKAP1 | -8.502 | Cell death |
| methionine adenosyltransferase II, alpha* | 171347 | MAT2A | -9.474 | Others/unclassified |
| FXYD domain-containing ion transport regulator 1* | 58971 | FXYD1 | -9.644 | Cellular growth and proliferation; gene transcription |
| CD24 antigen* | 25145 | CD24 | -11.299 | Cell death; cell morphology; cell signaling; cellular assembly and organization; cellular development; cellular growth and proliferation; cellular movement |
| nuclear receptor subfamily 1, group I, member 2* | 84385 | NR1I2 | -11.958 | Biomolecule metabolism; gene transcription; inflammation; molecular transport; post-translational modification |
| glial cell line derived neurotrophic factor family receptor alpha 1* | 25454 | GFRA1 | -17.708 | Cell death; cell morphology; cellular development; cellular; growth and proliferation; cellular movement |
| cell division cycle 25 homolog A (S. cerevisiae)* | 171102 | CDC25A | -19.859 | Cell cycle; cell death; cell morphology; cellular growth and proliferation; dna replication, recombination, and repair |
| 5-hydroxytryptamine (serotonin) receptor 5B* | 79247 | HTR5B | -22.285 | Others/unclassified |
| NSFL1 (p97) cofactor (p47)* | 83809 | NSFL1C | -22.400 | Others/unclassified |
| membrane and microfilament-associated protein p58* | 207121 | RGD: 727794 | -49.533 | Cellular assembly and organization |
*
The change in expression was significant compared with untreated control (P < .05). Gene names in italics are common in both panels of T + E2-treated LP and T + DES-treated VP.