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. 2007 Nov 16;7:231. doi: 10.1186/1471-2148-7-231

Figure 8.

Figure 8

Phylogenetic analyses of the LRR domain of all the proteins presenting a similarity with an expect value < 10–50 with at least one of the six LGR proteins. A: Neighbor-Joining tree comparing the amino acids sequences by the corrected p-distance. Bootstraps of 1000 samples are shown in percent. B: UPGMA tree comparing the LRR consensus established on the same set of proteins. This analysis, which measures the identity of the amino acids, was performed only on the LRR consensus established on relatively well conserved repeats: 50% or more relative positions of the 28-mere presenting an identical amino acid in 50% or more of the LRRs of a given protein. Both analyses show that the closest relative of LRRs of LGRs are the bacterial 24-meric LRRs of Legionella pneumophila and related bacteria and the 28-meres of eucaryotes.