Figure 3.

Shock reactivity in rats infused with CP101,606 prior to training. The mean shock reactivity of rats that received 4.5 μg/amygdala of CP101,606 prior to each two days of training (averaged response across days) was modestly but significantly lower than that of rats that received pretraining vehicle infusions. As noted previously however, these rats showed normal levels of fear potentiation. Shock reactivity in rats infused with 1.5 μg/amygdala, a dose that did disrupt fear conditioning, was normal. As such, effects on footshock perception cannot account for the conditioning deficits produced by pretraining intra-amygdala infusions of CP101,606.