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. 1997 Jun 1;109(6):731–740. doi: 10.1085/jgp.109.6.731

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Heating-activated outward current recorded in various internal and external solutions. Whole cell currents evoked by voltage pulses up to +100 (A) or +120 mV (B and C) in +10-mV increments at pH_p 5.5 (32°C). The holding potential was 0 mV. The internal solution was buffered with 120 mM Mes. Selected traces of tail currents (arrows) were magnified with superimposed single exponential fits (right). (A) The internal and external media contained K-glutamate and Na-isethionate, respectively. Tail currents induced by prepulse of +10, +30, +50, +70, and +100 mV are superimposed. (B) The internal and external media contained CsCl and Na-isethionate. Tail currents with prepulse of +10, +30, +40, +60, and +100 mV are superimposed. (C) The internal and external media contained K-glutamate and NaCl. Tail currents at +10, +70, +90, +100, and +120 mV are superimposed. 50 μM of DIDS was added into all external media. pH_o: 7.3 (A and B) and 6.0 (C).