Table II.
Caffeine-induced Na-Ca Exchange Current and Cai-transient at Holding Potential of −90 mV in Ventricular Myocytes from Nontransgenic (Control) and Transgenic Mice
| INa-Ca Density (pA/pF) | τINa-Ca-decay (ms) | Δ[Ca2+]i (nM) | τCai-decay (ms) | [Ca2+]i/dt (μM/s) | Capacitance (pF) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| control | 1.61 ± 0.16(14) | 304 ± 23 (9) | 410 ± 26(14) | 1,186 ± 282(12) | 4.8 ± 0.4(14) | 206 ± 11(14) | ||||||
| transgenic | 4.96 ± 0.63*(16) | 126 ± 13*(10) | 437 ± 31(16) | 486 ± 54*(16) | 5.1 ± 0.4(16) | 213 ± 9.0(16) | ||||||
| control | 1.32 ± 0.22 (3) | 388 ± 19 (3) | 764 ± 131 (3) | 5.1 ± 0.6 (3) | 1.88 ± 19 (3) | |||||||
| control + Ni2+ | 0.08 ± 0.08 (3) | 458 ± 13‡ (3) | 3,511 ± 1659 (3) | 4.2 ± 0.3 (3) | ||||||||
| transgenic | 5.52 ± 2.07 (4) | 422 ± 48 (4) | 457 ± 113 (4) | 6.2 ± 1.1 (4) | 206 ± 8 (4) | |||||||
| transgenic + Ni2+ | 0.13 ± 0.07 (4) | 698 ± 125§ (4) | 6,278 ± 1375§ (4) | 8.3 ± 1.2§ ‖ (4) |
Data are represented as the mean ± SEM (number of experiments).
*
Significantly different from control at P < 0.05.
‡
Significantly different from control at P < 0.05.
§
Significantly different from transgenic at P < 0.05.
‖
Significantly different from control + Ni2+ at P < 0.05.