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. 1997 Jan 1;109(1):15–26. doi: 10.1085/jgp.109.1.15

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Effects of introducing Cys residues in pre M2 segment at positions αS583, βG525, and γG537. (A) Single channel tracings of βG525C mutant recorded with Na⁺as permeating ion. (B) Left: I-V relationships of wt ENaC and αS583C mutant. Cord conductance for wt ENaC (wt) in the presence of Na⁺was 5.1 and 10 pS with Li⁺. Li⁺conductance of αS583C was 8.9 pS. Right: I-V relationships for βG525C and γG537C. In the presence of Na⁺and Li⁺ions, cord conductances were, respectively, 3.2 and 5.8 pS for βG525C, 4 and 6.23 pS for γG534C. Dotted lines represent fit of the data of the I-V relationships according to the constant field equation. Each point represents mean value of two to five channels.