Table III.
Inactivation Time Course in Cell-attached Macropatches at +30 mV
| τh(+30 mV) | n | τh(+30 mV) | n | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| F1483Q | 0.21 ± 0.01 | 6 | F1489Y | 0.48 ± 0.02 | 6 | |||||
| D1487A | 0.22 ± 0.01 | 6 | T1491M | 1.51 ± 0.24 | 4 | |||||
| D1487N | 0.22 ± 0.02 | 3 | Y1497Q | 0.33 ± 0.07 | 3 | |||||
| F1489A | 0.95 ± 0.05 | 6 | Y1498Q | 0.20 ± 0.02 | 5 | |||||
| F1489I | 0.46 ± 0.02 | 5 | YY1497/8QQ | 0.55 ± 0.04 | 8 | |||||
| F1489Q | 1.32 ± 0.13 | 3 | WT | 0.16 ± 0.01 | 13 |
τh(+30 mV) was derived from single exponential fits to the inactivation time course. τh(+30 mV) was significantly different from WT (P < 0.05) for all mutants tested.