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. 1997 May 1;109(5):607–617. doi: 10.1085/jgp.109.5.607

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Voltage dependence of macroscopic inactivation properties of proline mutants. (A) Voltage dependence of macroscopic inactivation. τ_h was determined from single exponential fits to the current decay in macropatch experiments. Averages from 4 to 16 experiments are shown for WT (○), P1509A (▴), and P1512A (▾). *The voltage for τ_h values of mutant channels was corrected for differences in the mean midpoints of the activation curves relative to WT. ΔV_1/2 relative to WT in macropatch experiments was +4 mV (P1509A) and +7 mV (P1512A). (B) Steady-state inactivation curves in response to 100-ms pulses. Data are averages of 4–7 two-electrode voltage-clamp experiments (Table I) with WT (○), P1509A (▴), and P1512A (▾). Solid lines are least-square fits of the Boltzmann equation to the data.