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. 1997 Mar 1;109(3):313–326. doi: 10.1085/jgp.109.3.313

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Single-channel Ba currents elicited by voltage ramps in a multi-channel patch. (A) Individual current traces elicited by 150-mV voltage ramps (1 s duration) from the resting potential. (B) Average of 16 records after leak subtraction. The leak, equivalent to a seal resistance of 290 GΩ, was determined from the slope of the initial part of the records which showed no channel openings (0–25 mV) in any of the averaged traces. A fit of a Boltzmann curve of the type I_max./{1 + exp [(V _h − HP)/k]} to the current below the peak of the I-V curve (up to 80 mV depolarization) gave a slope k of + 8.4 mV (for an e-fold change in current), +80 mV for the half-maximal activation V_hof the current, and −2.1 pA for I_max.. Experiment in the presence of 50 μM Bay K8644.