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pH dependence of CTX block of wild-type channels. (A) Block of current at the indicated CTX concentration at pH 7 (•) and 5.5 (○). Data at pH 7 are the averages of 3–10 observations, except for a single determination at 5 μM. Solid line as in Fig. 2 with indicated K d value. (B) pH dependence of block by 0.5 μM CTX. Data are the averages of 5–10 measurements; standard error limits omitted if smaller than symbol. Line was fit to data of Eq. 1 with indicated parameters.
