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. 1998 Mar 1;111(3):477–490. doi: 10.1085/jgp.111.3.477

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Effects of genistein on single channel open time and amplitude. All traces are 43 s in length. CFTR channels were first activated in a cell-attached mode as described in Fig. 2. (A) Prolongation of CFTR open time by genistein in Hi-5 insect cells. (top) Single CFTR channel activity in the presence of 0.5 mM ATP, and (bottom) in the presence of 0.5 mM ATP plus 5 μM genistein. (B) Effects of genistein on single channel amplitude. The amplitude histogram of the above record clearly shows a decrease in single channel amplitude in the presence of genistein. Gaussian fits of the amplitude histogram yielded amplitudes of O_ATP = 0.422 pA and O_{ATP + Genistein} = 0.291 pA (baseline subtracted). Note the increase in the width of the O_{ATP + Genistein} peak, indicating that more conductance states are present in the presence of genistein.

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