Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1998 Mar 1;111(3):477–490. doi: 10.1085/jgp.111.3.477

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Inhibition of forskolin- and calyculin A-stimulated CFTR activity by genistein in cell-attached modes. (A) When first applied to the external bath solution, 100 μM genistein enhanced CFTR activity, but after several minutes of application activity declined, suggesting a rate-limiting diffusion. This decline in CFTR activity was reversible after the start of washout of genistein. (B) Time course of genistein's inhibitory effect. Each 1-min trace is from a continuous recording from a Hi-5 cell prestimulated with 10 μM forskolin and 20 nM calyculin A. Recordings were made at various times after the start of genistein (100 μM) perfusion.

HHS Vulnerability Disclosure