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. 1998 Apr 1;111(4):583–599. doi: 10.1085/jgp.111.4.583

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Voltage dependence of EAG channel activation at 1 mM [Ca²⁺]_o and 1 mM [Mg²⁺]_o. (A) Current-to-voltage relation of bEAG channel-mediated whole-cell current. All currents are normalized to the current measured at +40 mV. Activation threshold for both channel forms is −50 mV. Mean values ± SD of normalized currents were recorded from eight (bEAG1, ▾) and seven (bEAG2, ○) different cells. The large standard deviations at V_m > 60 mV are due to decline of the current in some of the cells. (B) Activation kinetics of K⁺ currents after a step from −80 mV to the indicated membrane voltage. The dots represent values of current, lines represent fits of Eq. 1 to the data; dashed lines are for bEAG1, solid lines for bEAG2. The fits gave values of R, τ_fast, and τ_slow for bEAG1 (bEAG2) of: 0.78 (0.36), 4.2 (24.7), and 297 (146) ms at +40 mV, and 0.51 (0.16), 9.2 (24.7), and 408 (305) ms at −10 mV. (C) Voltage dependence of the activation time constants. (D) Voltage dependence of the fraction of the fast activating component, R.