Figure 12.

Correlations between successive openings. (A) Open-duration histograms for the patch in Fig. 4 exposed to 0.4 μM Ca²⁺ including all openings (left), openings after openings shorter than 1 ms (middle), and openings after openings longer than 10 ms (right). The lifetimes and relative amplitudes of the two components were 1.1 ms, 51%, and 13.5 ms for all openings; 1.1 ms, 80%, and 15.8 ms after short openings; and 1.3 ms, 26%, and 14.0 ms after long openings. Insets show corresponding histograms for simulations of the model in Fig. 10. The short and long components had lifetimes of 1.0 ms, 51%, and 12.2 ms for all openings; 1.0 ms, 77%, and 12.3 ms after short openings; and 1.1 ms, 19%, and 12.8 ms after long openings. (B) Open-duration histograms for the channel in Fig. 7 displaying low open probability behavior in 1.0 μM Ca²⁺. Open times were fit to two components with lifetimes of 0.9 ms, 71%, and 9.8 ms (left). Openings after openings shorter than 1 ms (middle) had lifetimes of 0.7 ms, 92%, and 8.8 ms. Openings after openings longer than 10 ms (right) were predominantly long but could not be fit due to the small number of events. Insets show corresponding histograms for the model in Fig. 11. The two components had lifetimes of 1.0 ms, 73%, and 11.4 ms for all openings; 1.0 ms, 91%, and 9.1 ms after short openings; and 1.2 ms, 24%, and 13.3 ms after long openings.