Figure 3.
Decay time constant τ of Ca current (single exponential fit) shortened as SR Ca loading increased. τ was first measured for ICa at pulse 1, for which the previously existing SR Ca load was 0. τ was then measured for Ca currents evoked by 2, 3, 6, and 11 pulses, for which just previous SR Ca load measurements were available (at 1, 2, 5, and 10 pulses, respectively). τ was also measured for ICa evoked by 20 and 40 pulses, but since load measurements were not done at 19 or 39 pulses and the SR Ca load was close to steady state, the respective SR Ca load measurements for 20 or 40 pulses were those made just afterward. τ for the various numbers of pulses were normalized to τ of the first (0 load) pulse and plotted against the corresponding SR Ca loads. A single regression line was fitted to all the data.