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. 1998 Apr 1;111(4):601–614. doi: 10.1085/jgp.111.4.601

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Gluconate conductance of CFTR pore mutants. Both R347D (A) and K335E (B) mediate macroscopic gluconate efflux with a similar apparent gluconate permeability to wild type (see Figs. 1 A, 2 B, 3, B and C, 5 D, and 8, A and B). (C and D) Relationship between mean gluconate current (I) and current variance (σ²) at −50 mV under symmetrical ionic conditions for R347D (C) and K335E (D), calculated as described in Fig. 6 A. In each case, the data have been fitted by Eq. 3 (see methods), giving i = 15.1 fA and n = 5,795 in C, and i = 12.1 fA and n = 6,967 in D.