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. 1998 May 1;111(5):639–652. doi: 10.1085/jgp.111.5.639

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Sodium currents of wild-type hH1 and two mutant channels, F1648Q/A1649Q and A1649Q. (A) Diagram of the amino acids in the S4–S5/D4 loop of hH1that were replaced either singly or doubly by glutamine residues (S¹⁶⁵³ was not examined). (B) Effects of F1648Q/A1649Q and A1649Q mutations in S4–S5/D4 segment of hH1 on families of Na⁺ currents. (top) WT human heart sodium channel subtype 1. (middle and bottom) F1648Q/A1649Q and A1649Q mutant channels, respectively, expressed transiently in tsA201 cells and activated by depolarization in 5-mV increments from −80 to +75 mV; holding potential, −120 mV.