Table II.
Data of Single Channel Analysis
| V | WT | A1649Q | R | P | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| mV | ||||||||||
| Peak P open | −20 | 0.30 ± 0.03 | 0.22 ± 0.02 | 0.73 | <0.05 | |||||
| −40 | 0.18 ± 0.02 | 0.13 ± 0.02 | 0.72 | <0.05 | ||||||
| Median first latency (ms) | −20 | 0.79 ± 0.12 | 0.77 ± 0.06 | 0.97 | NS | |||||
| −40 | 1.79 ± 0.30 | 0.93 ± 0.08 | 0.52 | <0.05 | ||||||
| τh (ms) | −20 | 0.71 ± 0.07 | 0.72 ± 0.04 | 1.01 | NS | |||||
| −40 | 2.77 ± 0.67 | 0.80 ± 0.14 | 0.23 | <0.01 | ||||||
| τopen (ms) | −20 | 0.25 ± 0.03 | 0.15 ± 0.02 | 0.60 | <0.01 | |||||
| −40 | 0.23 ± 0.03 | 0.16 ± 0.02 | 0.63 | <0.05 | ||||||
| Current amplitude (pA) | −20 | 1.80 ± 0.03 | 1.81 ± 0.03 | 1.0 | NS | |||||
| −40 | 1.93 ± 0.03 | 2.00 ± 0.02 | 1.05 | NS |
These data derive from nine and six patches in WT and A1649Q, respectively. Total sweeps are 1,336 (−20 mV) and 1,593 (−40 mV) for WT, 992 (−20 mV), and 1,042 (−40 mV) for A1649Q. R, ratio = A1649Q/WT. Data are expressed as mean ± SEM.