Figure 3.

(A) Idiosyncratic gating in the presence of Cs⁺. The bath contained K⁺-free Cs⁺ saline, and the pipette contained KMeSO₃. Pairs of identical 1-s depolarizing pulses were applied from V_hold = −80 mV, separated by a 20-ms repolarization to −80 mV, to –20 through +80 mV in 20-mV increments (nominal voltages). (B) Simulation of gating in the presence of Cs⁺. The same parameters as in other simulations were used, except that [K⁺]_o was reduced to 10 mM to mimic the reduced permeability of Cs⁺, and activation and deactivation rates were halved. Voltages in the simulation were corrected −7 mV for liquid junction potentials. Note the steeply voltage-dependent decay rate during the first pulses in A and B, but not in C.