Figure 7.

Caspase inhibitors suppress CD95- and UVB-mediated apoptosis differentially. Cells were treated with one of the caspase inhibitors z-VAD, z-DEVD, or z-IETD (20 μM each). Cells were UVB-irradiated or incubated with CD95L and an agonistic CD95-Ab, respectively, 1 hr later. Control cells were stimulated with the inhibitors only. Apoptosis was evaluated 16 hr later by using a cell death ELISA. Enrichment factor was used as a parameter of apoptosis and is given as the mean ± SD of three independently performed experiments.