Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2000 May 1;115(5):547–558. doi: 10.1085/jgp.115.5.547

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Effect of β-adrenergic stimulation on I_KACh of rat atrial cells. (A) Original whole cell current recordings at a membrane holding potential of −80 mV. I_KACh was induced by superfusion with ACh (10 μmol/liter) or ACh plus Iso (1 μmol/liter) in the absence (top) and in the presence (bottom) of 50 μmol/liter H89. (B) Statistics of the effect of Iso on I_KACh amplitude, shown as percent increase compared with I_KACh induced by ACh alone. Calculated average values ± SEM are shown; the number of individual cells is given in parenthesis. (* and **) Mean value deviates significantly (P < 0.05 and 0.01) from the H89 treated group. (Left to right) Effect of Iso coapplied with ACh (control, H89 treatment); additional I_KACh induced by Iso application during ACh (control, I_KACh recorded with nystatin perforated patch, H89 treatment). (C) Effect of Iso coapplication on kinetics of I _KACh activation. (Left to right) Regular I_KACh induced by ACh superfusion; I_KACh induced by ACh coapplied with Iso; same as previous, but in the presence of 50 μmol/liter H89. (Dotted line) Monoexponential fit through the rising phase of I _KACh. (Broken line) Biexponential fit, comprising a fast and an additional slow time constant.