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. 2000 May 1;115(5):547–558. doi: 10.1085/jgp.115.5.547

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Effect of heterologous Gα_s overexpression on basal and agonist-induced GIRK currents. (A) Statistics of effect of Gα_s overexpression on basal current, normalized to basal I_HK current of control (no Gα_s overexpressed). Calculated average values ± SEM from two different batches of oocytes are shown (three to five oocytes per batch). Individual experiments were performed either in the absence (white bars) or after preincubation (gray bars) of oocytes in 50 μmol/liter H89. (# and ##) Mean value deviates significantly (P < 0.05 and 0.01) from the corresponding basal current (same amount of Gα_s cRNA injected), but without H89 preincubation. (*, **, and ***) Mean value deviates significantly (P < 0.05, 0.01, and 0.001) from the basal current without Gα _s overexpression. (B) Same as in A, but agonist-induced GIRK currents are normalized to I_ACh of control (no Gα_s overexpressed).