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. 2000 May 1;115(5):621–635. doi: 10.1085/jgp.115.5.621

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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δS→T AChR unliganded gating. (A) Continuous single-channel traces of spontaneous openings recorded at approximately −100 mV. Note the multiplicity of closed- and open- time components. Display f_c ≅ 6 kHz. Openings are downwards. (B) Schematic representation of the residues occupying the M2 12′ position in δS→T receptors. (C) I-V curve under cell-attached conditions and least-square fit with a straight line.