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. 2000 May 1;115(5):621–635. doi: 10.1085/jgp.115.5.621

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Example bursts of unliganded openings of wild-type and M2 12′ mutant receptors. Display f_c ≅ 6 kHz. The different current amplitudes most likely reflect differences in the membrane potential. This is most evident in the case of the εT→P mutant, where a somewhat detached patch could have decreased the cell's membrane potential. Openings are downwards.