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Mutation of exon B-encoded NES interferes with nuclear export of p120ctn. MCF7 cells were transiently transfected with pEFBOSp120–3AB expressing the wild-type p120ctn isoform 3AB (a and b) or with pEFBOSp120–3ABNESmut expressing p120ctn isoform 3AB with a mutated NES (c and d). (a and c) Two days after transfection, the subcellular distribution of p120ctn was determined by staining with mAb pp120. (b and d) Nuclear DNA staining of the same cells as shown in a and c. (Bar = 20 μm.)
