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. 2003 Jan;121(1):37–47. doi: 10.1085/jgp.20028716

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Dequalinium applied to the extracellular surface appears to block from the inside. (A) Time-course for block by 1 μM dequalinium applied to the intracellular surface of an inside-out patch (open symbols) and 1 μM dequalinium applied to the extracellular surface of an outside-out patch (filled circles). Each time course was fit with a single exponential, with a τ = 53 ms for the inside-out patch and τ = 1,429 ms for the outside-out patch. The inset represents the voltage protocol used for these experiments. (B) Current response to a voltage protocol, as indicated above the data. Here, 1 μM dequalinium was applied to the extracellular surface of an outside out patch. The current decay at 100 mV indicates block and the relaxation at −100 mV represents unblock.