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. 2003 Mar;121(3):181–197. doi: 10.1085/jgp.20028707

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — PKA-independent stimulation of exocytosis by the cAMP-GEFII–selective agonist 8CPT-2Me-cAMP. (A) Capacitance increases (bottom) elicited by trains of 10 depolarizations from −70 to 0 mV (top) under control conditions (left), in the presence 100 μM 8pCPT-2Me-cAMP (middle) and in the simultaneous presence of the agonist and 0.5 mM Rp-cAMPs. (B) Mean increase in membrane capacitance (ΔC_m,n − ΔC_{m,n − 1}) during each individual depolarization of the train (n). Data are mean values ± SEM of 5–6 experiments. ^aP < 0.05, ^bP < 0.001, and ^cP < 0.01 for comparison between 8CPT-2Me-cAMP and control. ^dP < 0.01 and ^eP < 0.05 for comparison between the combination of 8CPT-2Me-cAMP and Rp-cAMPS and control. ^fP < 0.05 for comparision between 8CPT-2Me-cAMP and the combination of 8CPT-2Me-cAMP and Rp-cAMPS.