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. 2003 Mar;121(3):199–214. doi: 10.1085/jgp.20028723

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Copyright © 2003, The Rockefeller University Press

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Figure 12. — UDB of WT and mutant Na⁺ channels by flecainide, NU-FL, QX-FL, and lidocaine. (A) Currents were evoked by imposing conditioning trains of 100–600 pulses (−10 mV, 25 ms) from a holding potential of −100 mV at a frequency of 10 Hz. Pulses were applied until steady-state UDB was achieved. Bar graphs summarize steady-state UDB by flecainide (10 μM), NU-FL (100 μM), QX-FL (100 μM, internal), and lidocaine (300 μM) plotted as the fraction of current blocked in response to pulse trains. (B) Recovery of F1760A channels from drug block, measured as described in Fig. 3 legend, for flecainide (10 μM, left) and QX-FL (100 μM, internal, right).