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. 2003 Mar;121(3):199–214. doi: 10.1085/jgp.20028723

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Copyright © 2003, The Rockefeller University Press

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Figure 9. — Cell-attached recordings reveal flecainide access to LA-receptor through the cell membrane. (A) UDB of WT Na⁺ channels by external application of flecainide and QX-FL in cell-attached configurations. Currents were evoked by imposing conditioning trains of 100–200 pulses (−20 mV, 25 ms) from a holding potential of −120 mV at a frequency of 1 Hz. Pulses were applied until steady-state UDB was achieved. (B) Bar graphs summarize steady-state UDB by external application of flecainide and QX-FL plotted as the fraction of current blocked in response to pulse trains. n = 2–3 cells per condition.