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. 2003 Jun;121(6):495–510. doi: 10.1085/jgp.200208770

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Copyright © 2003, The Rockefeller University Press

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Figure 2. — Measured parameters and fits for recombinant N-type channels (α_1B/β_2a/α₂δ). (A) For a particular voltage, willing-reluctant interchange is modeled as a single upward and downward rate. (B₁ and B₂) Time constants, τ(V), and fraction of channels in the willing mode, W(∞,V), were collected using protocols described in Fig. 1. Fits were obtained using Eqs. 1–5 and simultaneously fitting both parameters using least squares protocol. (B₃) Off rates, k _off(V), were determined by combining Eqs. 1 and 2 such that: k _off (V) = W(∞,V)/τ(V). The smooth fit was obtained by plotting Eq. 5 using parameters determined with fits from parts B₁ and B₂. (B₄) The on rates, k _on(V), were also determined by combining Eqs. 1 and 2 where: k _on(V) = (1 − W(∞,V))/τ(V). Fits were obtained by inserting the values determined in B₁ and B₂ into Eq. 4. All concentration values, [Gβγ], for this figure and all following figures are set to one, assuming that concentration on average is equal.