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. 2003 Jun;121(6):551–561. doi: 10.1085/jgp.200208753

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — (A) Scheme summarizing the influence of transmembrane potential on the interaction of ryanoids with the high-affinity binding site of RyR (Tanna et al., 2000). L represents the ligand (any ryanoid) and + and − indicate the application of positive and negative holding potentials to the cytosolic side of the channel. A minimum of two forms of the vacant receptor exist in this model (open RyR which is low affinity and open RyR* which is high affinity). (B) Rate theory representation of scheme A. A shift from a negative to a positive holding potential increases the free energy of the free RyR (RyR to RyR*) and decreases the free energy of the RyR–ryanoid complex (RyR.L to RyR*.L). See text for details.