Figure 5.
Amplitude of potentiated tail current as a function of repolarization (Vrep) and the dependence of potentiated tail current amplitude on the prior test potential (Vtest). (A) Depolarization-induced increase of tail current amplitude as a function of Vrep (ranging from −50 to 50 mV) using the general protocol described in Fig. 4 in the absence (closed symbols, n = 10) and presence (open symbols, n = 8) of 10 μM (−)BayK 8644. The voltage-dependent increase in tail current amplitude (ΔI) at each Vrep was determined by subtracting the amplitude measured following the Vtest to 50 mV from that measured after the Vtest to 100 mV (see inset). (B) Tail current amplitude measured 20 ms after repolarization to −50 mV was measured as a function of Vtest (inset) in the presence of 10 μM (−)BayK 8644 (n = 6).