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. 2003 Jun;121(6):541–550. doi: 10.1085/jgp.200308833

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — Removal of intracellular Mg²⁺ greatly reduces fractional decay of both inward and outward currents via E2A/E4A-α_1C. Fractional decay of current was measured as the difference between the peak and steady-state current amplitudes divided by the peak current amplitude and is shown for both inward (top panel, V_test of −20 to 20 mV) and outward (bottom panel, V_test of 50–100 mV) currents. Data are shown for a pipette solution containing Mg²⁺ (circles) and for a Mg²⁺-free pipette (triangles). Both in the absence (filled symbols) and presence (open symbols) of (−)BayK 8644, the Mg²⁺-free pipette solution almost completely eliminated the decay of inward and outward currents.