Figure 10.

Characteristics of rate constants (k₁ in Fig. 9 G) for block of IRK1 by alkyl-bis- and mono-amines of varying chain length. The values (mean ± SEM; n = 5) were obtained from linear fits as illustrated for alkyl-bis- and mono-C9 in Fig. 9, E and F. (A) Rate constants extrapolated to 0 mV, k₁(0 mV), for IRK1 block by bis-amines and mono-amines are plotted against alkyl chain length. (B) Observed valence of rate constants (z₁) for IRK1 block by bis-amines and mono-amines, plotted against alkyl chain length.