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. 2003 Apr;121(4):261–276. doi: 10.1085/jgp.200208771

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Copyright © 2003, The Rockefeller University Press

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Figure 3. — Effects of substituting aspartate in M2 of KcsA-IRK1 on inward rectification. (A–D) Currents of original KcsA-IRK1 and mutants containing Asp at three representative positions. (E) Absolute ratio of steady-state currents (mean ± SEM; n = 5–10) at 80 and at −80 mV for the original and the Asp-substituted KcsA-IRK1 constructs.