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. 2003 Apr;121(4):261–276. doi: 10.1085/jgp.200208771

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Copyright © 2003, The Rockefeller University Press

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Figure 9. — Kinetics of voltage jump-induced IRK1 current relaxations in the presence of bis- and mono-amines. (A and B) Current traces at three concentrations of bis-C9 (A) or mono-C9 (B) elicited by stepping membrane voltage from 0 to 70 mV. The curves superimposed on the current transients are single exponential fits. (C and D) Reciprocals of the time constants (1/τ; mean ± SEM, n = 5), obtained from the fits shown in A and B, are plotted against bis-C9 (C) and mono-C9 (D) concentrations and fitted with straight lines. (E and F) Natural logarithms of the slopes (k₁ in G) of the linear fits shown in C and D are plotted against membrane voltage and fitted with straight lines: ln k₁ = ln k₁(0 mV) + z₁VF/RT. (G) A kinetic model with one open (O) and two blocked states (B₁ and B₂).