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. 2003 May;121(5):413–425. doi: 10.1085/jgp.200308803

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Copyright © 2003, The Rockefeller University Press

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Figure 6. — AnxA4 binds to liposomes that mimic the cytoplasmic leaflet of the MDCK apical membrane and significantly reduces water permeability. (A) Quasielastic light scattering reveals that cytoplasmic leaflet liposomes aggregate in the presence of Ca²⁺ and Anx4. (B) Stopped-flow tracings of control and Anx-inhibited water flux in cytoplasmic lipid liposomes at 37°C. (C) Water permeability at 25°C is unaffected by Ca²⁺, but is significantly reduced when Anx4 is added for 20 min. EDTA reverses the inhibition (n = 3; mean ± SEM, **, P < 0.01). (D) The inhibition of water permeability is enhanced at 37°C and results in an overall reduction of 31% (P < 0.001).