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. 2004 Mar;123(3):191–204. doi: 10.1085/jgp.200308966

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Depolarization-induced exocytosis. (A) Transient Cl⁻ currents (bottom) and increase in cell capacitance (middle) triggered by a train of ten 500-ms depolarizations from −70 to 0 mV in an infected β-cell. (Inset) A part of the recording (marked by the dashed box) on an expanded time base, including five transient Cl⁻ currents. Note that the driving force for Cl⁻ ions is inward (corresponding to an upward deflection of the current trace) at 0 mV and outward at −70 mV with the solutions used. While some transient currents were observed between the depolarization pulses, no events were observed before the train. (B) Number of Cl⁻ current transients (N) elicited by the individual depolarization pulses during trains of 10 500-ms depolarizations from −70 to 0 mV during a first train (black bars) and a second train applied 2 min later (white bars, n = 5).